There are many women who suffer very annoying pregnancies, with many nausea, dizziness and even vomiting, which incapacitates them to do almost anything and makes them even run the risk of becoming dehydrated. Without going to this extreme, there are many women who spend bad mornings, or bad days, and who are vomiting almost anywhere (a coworker explained to me once she vomited so much that she was on the street talking, she stopped a moment , vomited to the side and continued as if nothing).
The fact is that many are prescribed Cariban and not all work the same. Many are better off taking it, but many others are not, and end up looking for an alternative. Another acquaintance confessed to me once that he was taking Primperán on his own and that the gynecologist "put in an impressive anger." As well, a recent study seems to show that Primperán, whose active substance is metoclopramide, It is safe during pregnancy.
The study was carried out in Denmark and they had a sample of 1,222,503 pregnant women who had taken Primperán or not (1 in 4 had taken it), analyzing the histories of pregnancy and subsequent delivery.
In order to obtain such a large number of cases, they took birth records between 1997 and 2011 and looked for possible side effects in infants, mainly looking for congenital malformations, spontaneous abortions and fetal death.
When assessing data related to major congenital malformations they did not observe significant differences between the mothers who took Primperán and those who did not. There were also no differences when comparing babies who had other malformations such as neural tube defects, transposition of large vessels, ventricular septum defects, tetralogy of Fallot, cleft lip, cleft palate, etc. (They looked at the 20 most common malformations).
They also found no association between the risk of spontaneous abortion and the medication. since, in fact, those who did not take more abortions (which does not necessarily mean that Primperán helps prevent a miscarriage) nor greater risk of fetal death.
Dr. Björn Pasternak, one of the authors of the study, said the following:
This is the largest study that, by far, has been conducted on the safety of metoclopramide during pregnancy, and as such substantially expands the published evidence on this issue ... the use of metoclopramide during pregnancy was not associated with an increase of the risk of significant adverse outcomes, which includes major malformations and the death of the fetus, and thus supports what is known about the safety of this medicine.
These data make metoclopramide, or Primperán, a possible route of treatment to the nausea and vomiting of many pregnant women who do not take anything because they believe, or are told, that they cannot take anything. Obviously, the less medication the better, however, as I said, there are women who are totally incapacitated by the symptoms to the point of running the risk of becoming dehydrated, and if it is known that the risk is low, or directly zero, there is no reason not to prescribe it.
It can serve, in fact, as an alternative, since in the same way that the Cariban does not work with all pregnant women, it has been seen that Primperán has the same effect, that is, not all of them have the expected effect and many They have to end up taking another alternative.
The only question I have left is to know if they came to value the Metoclopramide symptoms for the mother. It is known that Primperán has an effect on dopamine receptors in the brain and may cause extrapyramidal symptoms (tremors, spasms, involuntary movements, etc.), which discourage its use in older people and children up to 18 years of age and although it seems totally to the fetus Sure, I can't say the same about the mother because it doesn't seem to have taken it into account.
